Table 1.

Strategies to induce beta cell replication

	Rodents	Human islets	References
KO Cyclin D2	Effective	NA	Georgia et al. 2010
Increase Ezh2	Effective	NA	Zhou et al. 2013
Senolytic therapies	TBD	TBD	Palmer et al. 2015
Glycolytic flux and glucokinase activator.	Effective	Led to DNA damage, growth arrest and apoptosis.	Salpeter et al. 2010, 2011, 2013; Porat et al. 2011; Rieck et al. 2012; Tornovsky-Babeay et al. 2014
Adenosine kinase inhibitors	Effective	Not effective	Annes et al. 2012
Silencing of CDKN2C/p18 or CDKN1a/p21	TBD	Effective	Robitaille et al. 2016
Harmine	Effective	Effective (also induces α-cell proliferation)	Wang P et al. 2015, Wang YJ et al 2016
Aminopyrazine	Effective	Effective	Shen et al. 2015
SerpinB1	Effective	Effective	El Ouaamari et al. 2016