(A) Body weight after 3 days of caloric restriction (or ad lib caloric intake in the controls). (B)–(D) Fasting plasma glucose, insulin, and non-esterified fatty acid concentrations. (E)–(F) Plasma and liver triglyceride concentrations. (G) Liver membrane diacylglycerol. (H) PKCε membrane/cytosol ratio. In all panels, data are the mean±S.E.M. of n=6 per group, with comparisons by t-test. *P<0.05, **P<0.01, ***P<0.001. See also Fig. S1 and Table S1.