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. 2017 Dec 26;30(1):29–35. doi: 10.5021/ad.2018.30.1.29

Table 3. Histopathologic findings of cutaneous lesions in 12 specimens from perieschar erythematous lesions of tsutsugamushi disease (n=12).

Histopathologic feature 1 2 3 4 5 6 7 8 9 10 11 12 Patient (n, %)
Epidermis
 Ulceration 0 (0)
 Parakeratosis + + + + + + 6 (50.0)
 Exocytosis of mononuclear cells + + + + + + + + + 9 (75.0)
 Individual cell necrosis + + + + + 5 (41.7)
 Basal vacuolar changes + + + + + + 8 (66.7)
 Erythrocyte extravasation 0 (0)
Dermis
 Mononuclear cell infiltration
 Perivascular + + + + + + + + + + + + 12 (100.0)
 Interstitial + + + + + + + + + + 10 (83.3)
 Perineural + + + + + + + + + + 10 (83.3)
 Perifollicular + + + 3 (25.0)
 Around eccrine glands + + + + + + + + + + + + 12 (100.0)
 With neutrophils 0 (0)
 With eosinophils + 1 (8.3)
 With plasma cells + + + + + + + + + + + 11 (91.7)
 With atypical cells + + + + + + + + + + + 11 (91.7)
 With mitotic figures + + + + + + + + + + 10 (83.3)
 With lymphocytic dusts + + + + + + 6 (50.0)
 Vasculitis
 Leukocytoclastic 0 (0)
 Lymphocytic + + + + + + + + + + + + 12 (100.0)
 Fibrinoid necrosis of vessel walls + + + + + + + + + + + + 12 (100.0)
 Extravasation of erythrocytes + + + + + + + + + + + + 12 (100.0)
 Thrombosis + + + + + + + + + + 10 83.3)
 Subepidermal edema + + + + + + + + + + 10 (83.3)
Subcutaneous tissue
 Panniculitis + + + + + + + + + + 10 (83.3)