Table 3. Histopathologic findings of cutaneous lesions in 12 specimens from perieschar erythematous lesions of tsutsugamushi disease (n=12).
Histopathologic feature | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | Patient (n, %) |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermis | |||||||||||||
Ulceration | − | − | − | − | − | − | − | − | − | − | − | − | 0 (0) |
Parakeratosis | − | − | − | − | + | − | + | + | + | + | + | − | 6 (50.0) |
Exocytosis of mononuclear cells | − | − | + | + | + | + | + | + | − | + | + | + | 9 (75.0) |
Individual cell necrosis | + | − | + | − | − | + | − | − | + | + | − | − | 5 (41.7) |
Basal vacuolar changes | − | + | + | − | − | + | + | + | + | − | − | − | 8 (66.7) |
Erythrocyte extravasation | − | − | − | − | − | − | − | − | − | − | − | − | 0 (0) |
Dermis | |||||||||||||
Mononuclear cell infiltration | |||||||||||||
Perivascular | + | + | + | + | + | + | + | + | + | + | + | + | 12 (100.0) |
Interstitial | + | + | − | + | + | + | + | − | + | + | + | + | 10 (83.3) |
Perineural | + | + | − | + | + | − | + | + | + | + | + | + | 10 (83.3) |
Perifollicular | − | − | − | − | − | + | + | − | − | + | − | − | 3 (25.0) |
Around eccrine glands | + | + | + | + | + | + | + | + | + | + | + | + | 12 (100.0) |
With neutrophils | − | − | − | − | − | − | − | − | − | − | − | − | 0 (0) |
With eosinophils | − | − | − | − | − | − | − | + | − | − | − | − | 1 (8.3) |
With plasma cells | + | + | + | − | + | + | + | + | + | + | + | + | 11 (91.7) |
With atypical cells | + | + | − | + | + | + | + | + | + | + | + | + | 11 (91.7) |
With mitotic figures | + | − | − | + | + | + | + | + | + | + | + | + | 10 (83.3) |
With lymphocytic dusts | − | + | − | − | + | + | − | + | − | − | + | + | 6 (50.0) |
Vasculitis | |||||||||||||
Leukocytoclastic | − | − | − | − | − | − | − | − | − | − | − | − | 0 (0) |
Lymphocytic | + | + | + | + | + | + | + | + | + | + | + | + | 12 (100.0) |
Fibrinoid necrosis of vessel walls | + | + | + | + | + | + | + | + | + | + | + | + | 12 (100.0) |
Extravasation of erythrocytes | + | + | + | + | + | + | + | + | + | + | + | + | 12 (100.0) |
Thrombosis | + | − | − | + | + | + | + | + | + | + | + | + | 10 83.3) |
Subepidermal edema | + | − | + | + | + | + | − | + | + | + | + | + | 10 (83.3) |
Subcutaneous tissue | |||||||||||||
Panniculitis | + | − | + | + | + | + | + | + | − | + | + | + | 10 (83.3) |