Table 2. Prevalence of phenotypic alleles of HLA DQB1 for patients with pemphigoid and organ donors, HCFMUSP, 2016.
| HLA DQB1 | Pemphigoid (n=34) | Control (n=594) | OR (95% CI) | p-value*,† |
|---|---|---|---|---|
| DQB1*02:01 | 0 | 59 (9.9) | NA | NA |
| DQB1*02:02 | 2 (5.9) | 74 (12.5) | 0.44 (0.10~1.87) | 0.266 |
| DQB1*02:03 | 0 | 1 (0.2) | NA | NA |
| DQB1*03:01 | 13 (38.2) | 84 (14.1) | 3.76 (1.81~7.79) | 0.000372‡ |
| DQB1*03:02 | 1 (2.9) | 52 (8.8) | 0.32 (0.04~2.36) | 0.261 |
| DQB1*03:03 | 1 (2.9) | 9 (1.5) | 1.97 (0.24~16.01) | 0.526 |
| DQB1*03:04 | 0 | 1 (0.2) | NA | NA |
| DQB1*03:19 | 0 | 13 (2.2) | NA | NA |
| DQB1*04:01 | 0 | 2 (0.3) | NA | NA |
| DQB1*04:02 | 4 (11.8) | 42 (7.1) | 1.75 (0.59~5.21) | 0.313 |
| DQB1*04:04 | 0 | 2 (0.3) | NA | NA |
| DQB1*05:01 | 3 (8.8) | 83 (14.0) | 0.60 (0.18~1.99) | 0.401 |
| DQB1*05:02 | 1 (2.9) | 18 (3.0) | 0.97 (0.13~7.49) | 0.976 |
| DQB1*05:03 | 0 | 21 (3.5) | NA | NA |
| DQB1*05:07 | 0 | 2 (0.3) | NA | NA |
| DQB1*06:01 | 0 | 5 (0.8) | NA | NA |
| DQB1*06:02 | 5 (14.7) | 59 (9.9) | 1.56 (0.58~4.19) | 0.375 |
| DQB1*06:03 | 3 (8.8) | 38 (6.4) | 1.42 (0.41~4.84) | 0.579 |
| DQB1*06:04 | 1 (2.9) | 18 (3.0) | 0.97 (013~7.49) | 0.976 |
| DQB1*06:05 | 0 | 1 (0.2) | NA | NA |
| DQB1*06:08 | 0 | 1 (0.2) | NA | NA |
| DQB1*06:09 | 0 | 3 (0.5) | NA | NA |
| DQB1*06:11 | 0 | 4 (0.7) | NA | NA |
| DQB1*06:19 | 0 | 1 (0.2) | NA | NA |
| DQB1*06:27 | 0 | 1 (0.2) | NA | NA |
Values are presented as number of alleles (%). HCFMUSP: Faculdade de Medicina da Universidade de Sao Paulo (Faculty of Medicine of the University of Sao Paulo), OR: odds ratio, CI: confidence interval, NA: not evaluable. *p-value using logistic regression. †Significance level with Bonferroni correction for α=0.05: α/10=0.05/10=0.005 or α=0.01: α/10=0.01/10=0.001. ‡Significant p<0.001.