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. 2016 Jan 25;6(3):137–149. doi: 10.1016/j.jpha.2016.01.003

Table 8.

Performance characteristics of liquid chromatography–mass spectrophotometric(LC–MS) methods.

S.No. Method Detection Linear range (µg/mL) LOD (µg/mL) LLOQ Application Reference
1 LC–MS/MS with positive ion electrospray ionization Multiple reaction monitoring 0.005–2 Human plasma, bioequivalence study [58]
2 LC–MS/MS Positive ion mode Monitoring 0.0000679 µg/mL Human and minipig plasma [59]
3 LC–MS/MS Positive ion mode detection 0.001–2 0.001 Human plasma to bioequivalence study [60]
4 LC–MS/MS Positive ion mode detection 0.01 µg/g Human hair [61]