Table 3.
Main pharmacokinetic parameters of deoxyglycychloxazol after oral administration of 10 mg/kg to rats (Female/male: n=3, Total: n=6, Mean±SD).
| Pharmacokinetic parameters | Deoxyglycychloxazol |
||
|---|---|---|---|
| Female | Male | Total | |
| Cmax (ng/mL) | 563±93.3 | 388±36.2 | 475±115 |
| Tmax (h) | 8±0 | 8±0 | 8±0 |
| t1/2 (h) | 35.2±20.1 | 82.0±17.0 | 58.6±30.6 |
| CL (L/kg h) | 585±78.1 | 565±199 | 575±136 |
| AUC0−t (ng h/mL) | 11,985±2573 | 11,668±2636 | 11,827±2336 |
| AUC0−∞ (ng h/mL) | 15,135±4976 | 19,344±6140 | 17,239±5505 |
Cmax: the maximum plasma concentration.
Tmax: the time to reach peak concentration.
t1/2: the terminal elimination half-life.
CL: the plasma clearance.
AUC0−t: the area under the curve from zero to the last sampling time.
AUC0−∞: the AUC0−t extrapolated to infinity.