Table 3. Correlation between patient characteristics and pathogenic germline variants in BRCA1/2 or any tested genes among 230 patients with OC^a.

Clinicopathological features	n	Pathogenic BRCA1/2 mutation		P valueb	Pathogenic mutations in any tested gene		P valueb
		Positive	Negative		Positive	Negative
Age
<55	117	20	97	0.0132	28	89	0.0159
≥55	113	7	106		13	100
Histologic subtypec
HGSC	74	22	52	<0.0001	30	44	<0.0001
Non-HGSC	156	5	151		11	145
Stage
I	107	11	96	0.5460	21	86	0.6050
II - IV	123	16	107		20	103
Personal history of breast cancera
Diagnosed with breast cancer	6	2	4	0.1480	3	3	0.0714
Not diagnosed with breast cancer	224	25	199		38	186
One or more family members with breast cancera,d
Present	26	5	21	0.3260	6	20	0.4040
Absent	154	17	137		25	129
One or more family members with ovarian cancera,d
Present	13	6	7	0.0017	7	6	0.0019
Absent	167	16	151		24	143
One or more family members with ovarian or breast cancera,c
Present	32	7	25	0.0775	9	23	0.1180
Absent	148	15	133		22	126

^aAmong 230 patients, a detailed family history was available for 180 patients.

^bFisher's exact test.

^cHGSC, high-grade serous carcinoma.

^dFamily history of cancer, including first- or second-degree relatives.