Figure 10. Expression changes of ASK1, Gclm, c-Jun and p38 were assessed in human SLC7A11-AS1^low gastric cancer tissues.

(A) The protein level of ASK1, Gclm and c-Jun were increased and p38MAPK was decreased in 30 paired SLC7A11-AS1^low GC tissues compared with ANTs, expression levels were normalized to GAPDH levels. (B) The expression of ASK1 (P = 0.027) and Gclm (P = 0.217) mRNA level were up-regulated and p38 (P = 0.638) and c-Jun (P = 0.193) mRNA levels were down-regulated in 30 paired SLC7A11-AS1^low group GC tissues and respective ANTs. Expression levels were normalized to β-actin levels. Results are shown as mean ± SEM. (^*P < 0.05, NS: No significantly, Ca: cancer tissue, N: respective ANTs, two-tailed Student's t-test)