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(A) Schematic of an ELISA system designed to identify chemical compounds that inhibit the MKK7-TIPRL interaction. (B) Flowchart for the selection of the hit chemical compound, TRT-0002, from over 6,000 chemical compounds. (C) Flowchart for the selection of the lead compounds, TRT-0029 and TRT-0173, from 280 analogs of TRT-0002.
