Table 3. Genetic pathways that are associated (top five in magnitude) with important-significant (i.e “relevant”) imaging habitats.

	Habitat 2	Habitat 7	Habitat 10
Upregulated Pathways	Positive regulation of NFκB transcription-factor activity	DNA damage response signal transduction by p53 class mediator resulting in induction of apoptosis	Positive regulation of tyrosine phosphorylation of STAT-1
	Sphinganine 1-phosphate	Macrophage activation	Natural killer cell activation
	T cell proliferation during immune response	Neuron projection morphogenesis	Wnt receptor signaling pathway
	Cytokine production during immune response	Positive regulation of tyrosine phosphorylation of STAT-1	Mol beta2 estradiol
	T helper 2 cell differentiation	Natural killer cell activation	cAMP biosynthetic process
Downregulated Pathways	Dendrite morphogenesis	Monocyte differentiation	Potassium channel inhibitor activity
	Calcineurin A alpha beta B1	Response to DNA damage stimulus	Voltage gated calcium channel activity
	Proteasomal ubiquitin dependent protein catabolic process	T-cell differentiation	Positive regulation of cyclin dependent protein kinase activity
	IGF 1R heterotetramer	Cell morphogenesis	Regulation of S phase of mitotic cell cycle
	Negative regulation of DNA binding	Actin cytoskeleton reorganization	Schwann cell development