Table 2. Pooled sensitivities and specificities of evaluation of DNA methylation by subgroups.

	Sensitivity [95% CI]	Specificity [95% CI]	+LR [95% CI]	-LR [95% CI]	DOR [95% CI]	AUC [95% CI]
Overall	57% [50–63%]	97% [95–98%]	19.1[11.0–33.0]	0.45 [0.38–0.52]	42 [24−74]	0.88 [0.85–0.91]
Sample types
Serum–based	50% [43–58%]	98% [96–99%]	25.0 [13.2–47.5]	0.51 [0.44–0.59]	49 [25−95]	0.91 [0.88–0.93]
Plasma–based	71% [59–81%]	89% [78–94%]	6.3 [3.2–12.2]	0.33 [0.23–0.47]	19 [8−44]	0.87 [0.84–0.89]
Number of markers
Single	52% [45–60%]	98% [96–99%]	21.4 [12.0–38.3]	0.49 [0.42–0.57]	44 [24−81]	0.90 [0.87–0.92]
Multiple	76% [64–84%]	85% [65–95%]	5.2 [2.1–12.8]	0.28 [0.20–0.40]	18 [7−47]	0.85 [0.82–0.88]
Stage
Early (I + II)	55% [47–64%]	96% [92–98%]	12.9 [6.6–25.0]	0.47 [0.39–0.56]	28 [13−59]	0.85 [0.81–0.88]
Advanced (III + IV)	68% [60–75%]	96% [92–98%]	15.5 [7.9–30.2]	0.33 [0.26–0.43]	46 [21−104]	0.91 [0.88–0.93]
Geographic regions
Asia	55% [48–62%]	97% [94–98%]	17.8 [10.2–31.1]	0.47 [0.40–0.54]	38 [22−67]	0.87 [0.84–0.89]
Other regions	80% [61–91%]	99% [66–100%]	120.1 [1.7–8579.0]	0.21 [0.10–0.43]	586 [10−35903]	0.97 [0.95–0.98]