Table 3. Independent predictor of HCC and LRE development.

Variables	Hepatocellular carcinoma				Liver-related event
	Univariate	Multivariate			Univariate	Multivariate
	P value	Hazard ratio	95% CI	P value	P value	Hazard ratio	95% CI	P value
Demographic variables
Age, years	< 0.001	1.065	1.038–1.093	< 0.001	< 0.001	1.057	1.034–1.081	<0.001
Male gender	0.173	-	-	-	0.398
Body mass index, kg/m2	0.853	-	-	-	0.725
Diabetes	0.335	-	-	-	0.230
Liver cirrhosis	< 0.001	2.724	1.495–4.965	0.001	< 0.001	2.299	1.362–3.881	0.002
On-going AVT	0.335	-	-	-	0.798
Laboratory variables
Total bilirubin, mg/dL	0.021	1.369	0.768–2.437	0.287	0.052
Serum albumin, g/dL	0.001	1.054	0.484–2.295	0.895	< 0.001	1.135	0.567–2.271	0.720
Aspartate aminotransferase, IU/L	0.582	-	-	-	0.999
Alanine aminotransferase, IU/L	0.163	-	-	-	0.140
Alpha-fetoprotein, ng/mL	0.733	-	-	-	0.650
HBeAg positivity	0.269	-	-	-	0.351
HBV DNA, log IU/mL	0.693	-	-	-	0.508
Platelet count, 109/L	< 0.001	0.996	0.991–1.001	0.144	< 0.001	0.994	0.989–0.999	0.012
Liver stiffness, kPa	< 0.001	1.047	1.018–1.077	0.002	< 0.001	1.047	1.021–1.074	< 0.001

HCC, hepatocellular carcinoma; LRE, liver-related event; CI, confidence interval; AVT, antiviral therapy; HBeAg, hepatitis B e antigen; kPa, kilopascal.