Table 3.
Clusters of significant gray matter reduction in patients with chronic migraine vs. healthy controls using uncorrected maps at p < 0.005
| Anatomical regions | Brodmann area | Cluster extent (mm3) | Montreal Neurological Institute coordinates (x, y, z) | Peak Z Score | T value | P value (cluster level p uncorrected) |
|---|---|---|---|---|---|---|
| Cluster 1 | 1624 | 0.0085 | ||||
| R Cerebellum (lobule VIIIa) | 27, −48, −48 | 4.01 | 4.53 | |||
| R Cerebellum (Crus II) | 45, −64, −48 | 3.01 | 3.22 | |||
| Cluster 2 | 1707 | 0.0073 | ||||
| L Middle temporal gyrus | BA21 | −58, −32, 0 | 3.75 | 4.17 | ||
| Cluster 3 | 1620 | 0.009 | ||||
| L Amygdala | −20, 2, −19 | 3.67 | 4.06 | |||
| L Temporal pole | BA38 | −27, 7, −25 | 3.62 | 4.0 | ||
| L Pallidum | −18, 0, 3 | 3.48 | 3.81 | |||
| L Orbitofrontal cortex | BA11 | −10, 30, −18 | 2.73 | 2.94 | ||
| Cluster 4 | 582 | 0.037 | ||||
| L Primary occipital cortex | BA17 | −9, −74, 10 | 3.83 | 3.25 | ||
| L visual association area | BA18 | −14, −90, 16 | 3.64 | 3.5 |
R right, L left