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. 2018 Jan 10;8:304. doi: 10.1038/s41598-017-18307-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Restoration of decrement in amplitude of compound muscle action potential (AP) in EAMG rat upon specific inhibition of AChE and subsequent inhibition of BChE. (A–C) Electromyographic traces of the 1st (black line) and the 200th (red line) action potentials in normal muscles (A), in muscles affected by EAMG (B) and after C547 administration in EAMG rat (C). (D) Mean decrement of amplitude of APs recorded in healthy rats, in EAMG-affected rats and after IP administration of pyridostigmine (Pyr; 0.1 mg/kg) or C547 (0.008 mg/kg). Data are presented as mean ± SEM pooled from ten animals in each group. Asterisk (*) indicates statistically significant difference (p < 0.05).