Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 10;8:304. doi: 10.1038/s41598-017-18307-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Co-inhibition of acetylcholinesterase and butyrylcholinesterase increases urinary bladder contractions recorded in vivo in rats affected by EAMG. (A) Representative individual urinary bladder basal contractions recorded in the same rat with intact cholinesterases (left) and after IP injection of non-specific cholinesterase inhibitor pyridostigmine at the dose of 0.1 mg/kg (right). (B) Mean amplitude of urinary bladder basal contractions recorded in diseased animals following inhibition of cholinesterase activity: acetylcholinesterase - by C547 (0.008 mg/kg), butyrylcholinesterase - by bambuterol (0.2 mg/kg) and both cholinesterases - by C547 together with bambuterol or by non-specific inhibitor pyridostigmine (0.1 mg/kg). (C) Mean basal tonus recorded in the same animals as amplitude of urinary bladder basal contraction. Data are presented as mean ± SEM pooled from ten animals in each group. Asterisk (*) indicates statistically significant difference (p < 0.05).