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. 2018 Jan 10;8:304. doi: 10.1038/s41598-017-18307-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Additive effects of specific inhibition of BChE and AChE on amplitude of contractions of rat urinary bladder strips. Specific inhibition of BChE by iso-OMPA (50 μM) enhances ACh-induced contractions. Similar levels of potentiation of contractions (≈20%) were observed when iso-OMPA was applied alone or upon application of various concentrations of C547 (0.5–50 nM) – a specific AChE inhibitor. Iso-OMPA has no significant additional effect when applied after pyridostigmine (1 μM) – a non-specific cholinesterase inhibitor. Data are presented as mean ± SEM pooled from ten urinary bladder strips in each group. Asterisk (*) indicates statistically significant difference (p < 0.05) from control. Cross sign (+) indicates statistically significant difference (p < 0.05) in effects of combined application of iso-OMPA (50 μM) and C547 (0.5–50 nM) and application of any given single concentration of C457. Hash/pound sign (#) indicates statistically significant difference (p < 0.05) in effects of C547 (50 nM) and pyridostigmine (1 μM).