Figure 3.

Amphetamine in adolescence alters dopamine connectivity in adulthood. A, Timeline of experimental procedures; n = 4 per group. B, The loPFC, vaiPFC, and daiPFC, respectively, are highlighted in increasingly pale shades of red. Line drawings were derived from Paxinos and Franklin (2013). C, Stereological quantification of dopamine varicosity density reveals that adults exposed to amphetamine during adolescence have about a 40% reduction in dopamine varicosity density in the oPFC compared to saline-treated controls. Bars represent mean ± standard error (Extended Data Fig. 3-1).