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. 2018 Jan 10;8:327. doi: 10.1038/s41598-017-18612-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MiR655 over-expression promotes cellular migration, invasion and proliferation, and knock-down of miR655 in COX-2 high cells reduce aggressive phenotypes. Comparison of (A) migration, (B) invasion and (C) proliferation of parental, empty vector (Mock) transfected, and miR655 over-expressing MCF7 and SKBR3 cells. Comparison of (D) migration, (E) invasion and (F) proliferation of MCF7-COX-2-655KD and SKBR3-COX-2-655KD, compared to Mock cells. The data are presented as a mean of triplicate independent experiments ± SEM. *Indicates p < 0.05, **indicates p < 0.01 compared to parental and Mock cell lines.