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. 2018 Jan 10;8:327. doi: 10.1038/s41598-017-18612-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MiR655 is over-expressed in breast tumors and negatively correlates with patient survival. (A) Box-and-whisker plot showing over-expression of miR655 in primary human breast tumors (n = 105), in comparison to non-tumor control tissue (n = 20). A more negative ΔCt value indicates a higher miRNA expression level. (B) Expression of miR655 in different stages of tumors. Very significant correlation exists between (C) miR526b and miR655 expression. There is a positive correlation between certain genes and miRNA expression, such as between (D) miR655 and COX2, (E) miR655 and EP4 and (F) stem cell marker ALDH and mir655 expression. (G) Kaplan-Meier curve demonstrating the inverse relationship between high miR655 expression and overall survival rates in primary human breast carcinomas (n = 511). *Indicates p < 0.01.