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. 2018 Jan 10;8:253. doi: 10.1038/s41598-017-18050-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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C42Band LNCaP Docetaxel drug response. C42B and LNCaP cells in 2D and 3D cultures were treated with Docetaxel in the indicated concentrations for 72 hours followed by metabolic activity and DNA content measurements. All results are represented as a percentage of the vehicle control values (data was collected from three independent experiments each had four replicate cultures n = 4). Statistical significance was calculated by two-way ANOVA compared to the corresponding values in 2D cultures (***P < 0.0001).