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. 2018 Jan 10;8:271. doi: 10.1038/s41598-017-18527-z

Figure 1.

Figure 1

Enhanced YAP expression and activity promotes drug resistance. HCC827 cells overexpressed with wild-type (YAP WT) or constitutively active YAP (YAP 5SA) were cultured in the presence of (A) gefitinib or (B) afatinib. (C) H1975 cells with YAP expression were treated with afatinib. The error bars represent the S.E. of 3 independent experiments. *P < 0.05, empty compared with YAP 5SA, and #P < 0.05, empty compared with YAP WT. Upregulated YAP protein levels and activity were detected in both YAP overexpressed groups in (D) HCC827 and (E) H1975 cells. The original blot of these samples was shown in Supplementary Figure S5A. The error bars represent the S.E. of 3 independent experiments. *P < 0.05, empty compared with YAP 5SA or YAP WT.