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. 2018 Jan 10;8:271. doi: 10.1038/s41598-017-18527-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of combined therapy of TKI and statin, as a YAP inhibitor. Subcutaneous xenograft model demonstrated the effect of combined therapy of afatinib and fluvastatin in the inhibition of TKI-resistant tumor. (A) Tumor size and (B) tumor weight measured in either vehicle or drug treated groups. (C) Analysis of the Taiwan National Health Insurance data sources revealed prolonged survival in TKI prescribed patients with regular statin use compared to no statin used patients.