Table 2.

Hydrolysis of Aβ peptides under study by the ACE N- and C- domains.

Enzyme	Products observed (backbone positions)		Bond cleaved
Substrate	N-ACE	C-ACE	N-ACE	C-ACE
Aβ(1–16)	1–14	1–13, 1–14	13–14	13–14, 15–15
Aβ(1–16)-[Amide]	6–16	ND*	5–6	ND
[Acetyl]-Aβ(1–16)-[Amide]	1–5, 6–16	ND	5–6	ND
[Acetyl]-ratAβ(1–16)-[Amide]	1–13	1–13, 1–14, 1–15	13–14	13–14, 14–15, 15–16

*Not detected (ND).