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. 2018 Jan 10;9:144. doi: 10.1038/s41467-017-02602-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — High frequency of alternative lengthening of telomeres (ALT) in adult LMS. a Detection of C-circles in LMS tumors and control cell lines (U2OS, positive control; HeLa, negative control). Shown are test samples (top row) and control samples (bottom row). ALT-positive samples, as inferred from the enriched C-circle signal, are indicated in red. ALT-negative samples are indicated in blue. +pol, with polymerase; −pol, without polymerase. b Measurement of telomere content in LMS tumors. Telomere quantitative PCR was performed on tumor and matched control samples, and telomere repeat signals were normalized to a single-copy gene (36B4; T/S ratio). Shown are the telomere contents of tumor samples relative to those of control samples (left) and the absolute telomere contents of tumor samples (right). c Recurrent alterations in telomerase maintenance genes in LMS tumors. Rows represent individual genes, columns represent individual tumors. Genes are sorted according to frequency of SNVs, indels, and CNAs (left). Bars depict the number of alterations for individual tumors (top) and genes (right). Types of alterations and ALT status are annotated according to the color codes (bottom). UTR untranslated region; n.d. not determined