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. 2018 Jan 10;8:243. doi: 10.1038/s41598-017-18657-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Node degree and frequency are positively correlated with chronic pain intensity. (a) The degree-frequency correlation coefficient positively correlates with the pain intensity. Each marker represents an individual. (b) The relationship between node degrees and median frequencies for all EEG channels from two exemplary subjects with low (1) and high (77) pain intensities. The individual with a high pain score displayed a positive relationship between node degree and median frequency of EEG channels, whereas no correlation is observed for the individual with low pain. Each circle and square represents an EEG channel.