Table 2.
Odds ratios (95% confidence intervals) for risk of type 2 diabetes according to tertiles of adiponectin, the Singapore Chinese Health Study.
| Tertiles of adiponectin concentrations | P for trenda | per 1 log µg/mL | |||
|---|---|---|---|---|---|
| T1 | T2 | T3 | |||
| Whole dataset | |||||
| Median (range) | 5.5 (1.4, 7.1) | 8.3 (7.2, 9.8) | 11.8 (9.9, 29.9) | ||
| Cases/controls | 328/191 | 173/191 | 70/189 | ||
| Model 1b | 1.00 | 0.55 (0.40, 0.76) | 0.19 (0.12, 0.30) | <0.001 | 0.16 (0.10, 0.25) |
| Model 2c | 1.00 | 0.67 (0.48, 0.95) | 0.31 (0.20, 0.51) | <0.001 | 0.26 (0.16, 0.42) |
| Model 3d | 1.00 | 0.80 (0.52, 1.23) | 0.30 (0.17, 0.55) | <0.001 | 0.26 (0.14, 0.48) |
| Limited to cases with baseline hemoglobin A1c ≥ 6.5% (48 mmol/mol) and their matched controls | |||||
| Median (range) | 5.5 (1.4, 7.0) | 8.1 (7.1, 9.7) | 11.8 (9.8, 29.9) | ||
| Cases/controls | 159/98 | 88/92 | 32/89 | ||
| Model 1b | 1.00 | 0.63 (0.41, 0.99) | 0.19 (0.10, 0.37) | <0.001 | 0.13 (0.07, 0.25) |
| Model 2c | 1.00 | 0.86 (0.53, 1.38) | 0.35 (0.17, 0.71) | 0.01 | 0.22 (0.11, 0.44) |
| Model 3d | 1.00 | 2.08 (0.87, 4.98) | 0.27 (0.08, 0.90) | 0.20 | 0.26 (0.09, 0.82) |
| Limited to cases with baseline hemoglobin A1c < 6.5% (48 mmol/mol) and all the controls | |||||
| Median (range) | 5.7 (2.1, 7.5) | 8.7 (7.6, 10.0) | 12.1 (10.1, 26.7) | ||
| Cases/controls | 185/101 | 71/96 | 36/95 | ||
| Model 1b | 1.00 | 0.38 (0.23, 0.62) | 0.18 (0.09, 0.33) | <0.001 | 0.18 (0.10, 0.34) |
| Model 2c | 1.00 | 0.47 (0.28, 0.80) | 0.29 (0.15, 0.58) | <0.001 | 0.32 (0.16, 0.63) |
| Model 3d | 1.00 | 0.57 (0.32, 1.04) | 0.32 (0.14, 0.70) | 0.003 | 0.32 (0.15, 0.70) |
| Limited to cases with baseline hemoglobin A1c < 6.0% (42 mmol/mol) and all the controls | |||||
| Median (range) | 5.9 (2.2, 7.5) | 8.7 (7.6, 10.0) | 12.2 (10.1, 26.7) | ||
| Cases/controls | 78/49 | 47/50 | 21/47 | ||
| Model 1b | 1.00 | 0.56 (0.29, 1.09) | 0.21 (0.09, 0.49) | <0.001 | 0.25 (0.11, 0.56) |
| Model 2c | 1.00 | 0.79 (0.38, 1.63) | 0.36 (0.14, 0.90) | 0.037 | 0.44 (0.17, 1.10) |
| Model 3d | 1.00 | 0.77 (0.34, 1.77) | 0.34 (0.12, 0.98) | 0.06 | 0.40 (0.14, 1.19) |
aLinear trend was tested by using the median level of each tertile of adiponectin.
bModel 1: adjusted for age at blood taken (continuous), smoking (never, ever smoker), alcohol intake (never, ever drinker), weekly moderate-to-vigorous activity (<0.5, ≥0.5 hours/week), education level (primary school and below, secondary or above), history of hypertension (yes, no), fasting status (yes, no), and body mass index (continuous);
cModel 2: Model 1 plus adjusted for high-sensitivity C-reactive protein, and the ratio of triglycerides to high-density lipoprotein cholesterol (both in tertiles).
dModel 3: Model 2 plus adjusted for random glucose and random insulin (both in tertiles).