Fig. 2.

Comparison of the cytotoxic effects of hTERT and ARE-hTERT promoter-driven CD:UPRT expression in lung cancer cell lines in the presence of 5FC. Relative viabilities of NCI-H1299 (A), Calu-1 (B), A549 (C), and NCI-H358 (D) cells transfected with pARE-hTERT-CD : UPRT (hatched bars), phTERT-CD : UPRT (blank bars), and pBK-CMV (mock, dotted bars) plasmids after incubation with indicated concentrations of 5FC are shown as average values ± SD of the percentage of viable cells relative to the viability of similarly transfected cells incubated in the absence of 5FC.