Fig. 4.

Comparison of the cytotoxic effects of hTERT and ARE-hTERT promoter-driven CD : UPRT expression in lung cancer cell lines in the presence of 5FC when combined with chemotherapeutic agents. NCI-H1299 (A) or A549 (B) cells were transfected with pARE-hTERT-CD : UPRT (hatched bars) or phTERT-CD : UPRT (blank bars) plasmid and incubated in the presence or absence (as indicated) of 10 μM of 5FC and 0.1 μM of doxorubicin (Dox) (A) or 500 μM of 5FC and 2 μM of etoposide (Eto) (B). Data are shown as average values ± SD of the percentage of viable cells relative to the viability of similarly treated cells incubated in the absence of 5FC and chemotherapeutic agents.