Table 2.
Distribution of alleles and genotypes of polymorphic regions of the examined genes in MI patients (n = 405) and controls (n = 198)
| Carriage of alleles and genotypes |
Patients, n (%) |
Controls, n (%) |
p | pcorr** | OR (95% CI) for significant differences** |
|---|---|---|---|---|---|
| rs562556 in PCSK9 | |||||
| A | 389(96) | 193(97) | NS | NS | |
| G | 102(25) | 65(33) | 0.013 | NS | 0.69 (0.47–1.00) |
| A/A | 303(75) | 133(67) | 0.013 | NS | 1.45 (1.00–2.10) |
| A/G | 86(21) | 60(30) | 0.010 | NS | 0.62 (0.42–0.91) |
| G/G | 16(4) | 5(3) | NS | NS | |
| rs7412, rs429358 (epsilon polymorphism) in APOE | |||||
| ε2 | 63(16) | 30(15) | NS | NS | |
| ε3 | 393(98) | 194(98) | NS | NS | |
| ε4 | 40(10) | 38(19) | 0.0013 | 0.0091 | 0.46 (0.28–0.75) |
| ε2/ε2 | 5(1) | 2(1) | NS | NS | |
| ε2/ε3 | 55(14) | 26(13) | NS | NS | |
| ε2/ε4 | 3(1) | 2(1) | NS | NS | |
| ε3/ε3 | 305(75) | 132(67) | 0.017 | NS | 1.52 (1.05–2.2) |
| ε3/ε4 | 33(8) | 36(18) | 0.00033 | 0.0023 | 0.40 (0.24–0.66) |
| ε4/ε4 | 4(1) | 0(0) | |||
| rs320 in LPL | |||||
| G | 192(47) | 85(43) | NS | NS | |
| T | 363(90) | 187(94) | 0.032 | NS | 0.51 (0.25–0.99) |
| G/G | 42(10) | 11(6) | 0.032 | NS | 0.51 (0.25–0.99) |
| G/T | 150(37) | 74(37) | NS | NS | |
| T/T | 213(53) | 113(57) | NS | NS | |
| rs1801133 in MTHFR | |||||
| C | 369(91) | 174(87) | NS | NS | |
| G | 206(51) | 106(54) | NS | NS | |
| C/C | 199(49) | 92(46) | NS | NS | |
| C/T | 170(42) | 82(41) | NS | NS | |
| T/T | 36(9) | 24(13) | NS | NS | |
| rs2070744 in eNOS | |||||
| C | 253(62) | 100(50) | 0.0034 | 0.024 | 1.63 (1.16–2.30) |
| T | 343(85) | 174(88) | NS | NS | |
| C/C | 62(15) | 24(12) | NS | NS | |
| C/T | 191(47) | 76(38) | NS | NS | |
| T/T | 152(38) | 98(50) | 0.0034 | 0.024 | 0.61 (0.43–0.86) |
| rs1333049 in the 9p21 region | |||||
| C | 313(78) | 155(78) | NS | NS | |
| G | 305(75) | 146(74) | NS | NS | |
| C/C | 100(25) | 52(26) | NS | NS | |
| C/G | 213(53) | 103(52) | NS | NS | |
| G/G | 92(22) | 43(22) | NS | NS | |
NS – not significant.
*The Bonferroni correction for the number of tests (multiple comparisons) was applied to the p values.
**p < 0.05.