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. 2017 Sep 15;25(2):229–240. doi: 10.1038/cdd.2017.144

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Decreased bone mass in Sirt3−/− mice. (a) Micro-CT images of the femurs of wild-type (Sirt3+/+) and SIRT3-knockout (Sirt3−/−) mice. In the analysis of the trabecular bone and architecture, the following parameters were calculated: (b) bone volume per tissue volume (BV/TV); (c) trabecular thickness (Tb.Th); (d) trabecular number (Tb.N); (e) trabecular spacing (Tb.Sp); (f) bone surface to bone volume (BS/BV); (g) structure model index (SMI); (h) connectivity density; and (i) bone mineral content (BMC). Data are presented as the means±S.E.M.; n=6 per group. *P<0.05, **P<0.01 versus relative control