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Schematic model of miR-20a in regulating drug response. MiR-20a increases drug sensitivity in breast cancer cells through reducing drug efflux by inhibiting P-gp in a MAPK1-dependent manner. In drug-resistant cells, the dysregulated histone methylation inhibits the expression of miR-20a. In addition, miR-20a decreased the expression of c-Myc by inhibiting the MAPK/ERK pathway and formed a feedback loop, thus controlling the drug response and growth signal of the cells
