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. 2018 Jan 10;8:343. doi: 10.1038/s41598-017-18702-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Co-localization analysis of epertinib and heme B in brain of IVMs with breast cancer. Correlation analysis between the tumor epertinib concentration and the tumor volume (µm³), r² = 0.02, number of metastases: n = 42, (A). Co-localization of epertinib (red) and heme B (green) in the brain sections of IVM with breast cancer (B and C), tumor concentration of epertinib: (B) tumor 3 > tumor 1 ≈ tumor 2, (C) tumor 2 > tumor 1. In the BR3 IVM sectioned brain, at 8 h after epertinib administration, only tumors 3 and 4 showed no correlation between tumor epertinib concentration (tumor 5 > tumor 1 > tumor 2, tumor 3 > tumor 4) and the ion intensity of heme B (D). The HER2 IHC image observed in tumor 3 and 4 in BR3 IVM with breast cancer is shown in (E).