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. 2018 Jan 10;8:302. doi: 10.1038/s41598-017-18729-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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D1 receptor is involved in Aβ-induced disruption of inhibitory input and hyperexcitability of pyramidal cells. (A) Example AP traces of a pair of nearby FS interneuron and excitatory neuron simultaneously recorded; (B) example traces of uIPSCs triggered by brief current injection to the FS interneuron and recorded in the pyramidal neuron before and after Aβ + SCH23390 application; (C) quantification of uIPSCs amplitude from FS interneurons before and after Aβ + SCH23390 application; (D) examples of action potential traces induced by 150 pA and 400 pA current injections before and after Aβ + SCH23390 application; (E) quantification of the APs frequencies at different current injections before and after Aβ + SCH23390 application; (F) examples of membrane potential responses induced by serial currents injection from −20 pA to 0 pA before and after Aβ + SCH23390 application; (G) quantification of cellular input resistance before and after Aβ + SCH23390 application.