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. 2016 Jul 9;6(6):404–409. doi: 10.1016/j.jpha.2016.07.001

Table 2.

Dissociation constants of alendronate sodium.

Source pKa1 pKa2 pKa3 pKa4
This work 2.43±0.16 7.55±0.14 10.80±0.02 11.99±0.08
Literaturea 2.72±0.05 8.73±0.05 10.50±0.10 11.60±0.10
Difference ±0.29 ±1.18 ±0.30 ±0.39
a

The pKa values are from the Merck Index.