Skip to main content
. 2017 Nov;187(11):2378–2387. doi: 10.1016/j.ajpath.2017.07.014

Figure 2.

Figure 2

Urethral volume decreases and prostate blood vessel volume increases in mice with enlarged prostates. A: Quantification of prostatic urethral volume from magnetic resonance imaging demonstrates a significant decrease on prostatic enlargement. B: Quantification of prostatic blood vessel volume demonstrates a significant increase in blood vessel volume before significant prostatic enlargement at 12 weeks. C: Hematoxylin and eosin staining of representative urethral sections at 15 weeks after treatment in both the testosterone and estradiol (T+E) and T-treated cohorts of mice reveals a narrowed urethral lumen. D: T2-weighted and time-of-flight (TOF) images illustrating changes in blood vessel volume in the T+E mice as compared to the testosterone alone (T-control) mice at 12 weeks. E: CD31 immunohistochemical staining reveals an increase in endothelial cells in prostatic glands in T+E treated mice as compared to T controls. ∗P < 0.05. Scale bars = 200 μm (C). Original magnification: ×2 (C); ×20 (E).