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. 2017 Sep 8;26(1):219–237. doi: 10.1016/j.ymthe.2017.09.007

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© 2017 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

OTX2 Induces the Expression of KCNJ13, RDH10, and SLC16A8 in Human iPS-Derived RPE Cells

(A) iPS-RPE characterization expressing melanin and cobblestone morphology. (B) iPS-RPE characterization by RPE-specific ZO-1 and MITF protein markers. (C) Relative OTX2 gene expression analysis in iPS-RPE cells infected with recombinant AAV vectors as indicated. (D) Relative qRT-PCR analysis of genes in iPS-RPE cells in AAV-OTX2- and OTX2L-transduced cells as indicated. Because GAPDH expression was found to be variable in hiPS-RPE, we used 18S rRNA for normalization. The data were compared to non-transduced cells. None of the genes showed significant change between uninfected and AAV-GFP-infected cells. All samples were normalized to GAPDH. Mean with SD (n = 3, ANOVA test).