Table 3. Long-term antibiotic prophylaxis of recurring urinary tract infection (after [31]).

Substance	Dosage	Anticipated UTI rate per patient year	Sensitivity	Collateral damage	Safety/adverse drug reactions (ADR)
Continuous long-term prophylaxis
Cotrimoxazole	40/200 mg 1 × daily	0–0.2	+(+)	++	++
Cotrimoxazole	40/200 mg 3 × weekly	0.1	+(+)	++	++
Trimethoprim	100 mg 1 × daily*1	0–1.5	+(+)	++	+++
Nitrofurantoin	50 mg 1 × daily	0–0.6	+++	+++	++
Nitrofurantoin	100 mg 1 × daily*2	0–0.7	+++	+++	++
Cefaclor	250 mg 1 × daily*3	0.0	n.d.	+	+++
Cefaclor	125 mg 1 × daily*3	0.1	n.d.	+	+++
Norfloxacin	200 mg 1 × daily*3	0.0	++	+	++
Ciprofloxacin	125 mg 1 × daily*3	0.0	++	+	++
Fosfomycin- trometamol	3 g every 10 days	0.14	+++	+++	+++
Postcoital single-dose prophylaxis
Cotrimoxazole	40/200 mg	0.3	+(+)	++	++
Cotrimoxazole	80/400 mg	0.0	+(+)	++	++
Nitrofurantoin	50 mg	0.1	+++	+++	++
Nitrofurantoin	100 mg*2	0.1	+++	+++	++
Cefalexin	250 mg*3	0.0	n.d.	+	+++
Cefalexin	125 mg*3	0.0	n.d.	+	+++
Norfloxacin	200 mg*3	0.0	++	+	++
Ofloxacin	100 mg*3	0.03	++	+	++

*¹In older studies, trimethoprim 50 mg was reported as equieffective to 100 mg; *²in the case of equieffectiveness, nitrofurantoin 50 mg is the dose of choice; *³to avoid collateral damage and above all increasing resistance; use only if the other substances cannot be used.

n.d., No data

Symbols as explained in Table 1