Table 1.
Novel genome-wide significant associations identified in Latino populations.
| Target gene | Lead variant | Odds ratio (95% CI) (Latino/EA) | P-value (Latino/EA) | MAF (Latino) | MAF (EU) | MAF (EA) | MAF (SA) | MAF (AA) | Reference |
|---|---|---|---|---|---|---|---|---|---|
| SLC16A11 | rs77086571 | 1.29 (1.20–1.38)/1.20 (1.14–1.26)a | 5.4 × 10−12/7.9 × 10−13 | 0.24 | 0.007 | 0.11 | – | 0.0037 | Williams et al. (4), Rusu et al. (13) |
| HNF1A | rs483353044 | 4.96 (1.75–9.92) | 2.39 × 10−9 | 0.0034 | 0.000024 | 0 | 6 × 10−5 | 0 | Estrada et al. (5) |
| Insulin-like growth factor 2 | rs149483638 | 0.78 (0.73–0.83) | 5.61 × 10−14 | 0.19 | 0.00008 | 0.008 | 3 × 10−5 | 0.0014 | Mercader et al. (16) |
a The association values in the EA population corresponds to variant rs312457, which is in high linkage disequilibrium with rs77086571 (R2 = 0.93). The association of this variant in other populations or the rest of the variants in non-Latino populations are not shown as there was not enough power to provide an accurate estimate of the effect sizes due to the low frequency in non-Latino populations.
MAF, minor allele frequency, taken from gnomAD (http://gnomad.broadinstitute.org/), EU, Europeans; EA, East Asian; SA, South Asians; AA, African Americans.