Table 2.
Cox proportional hazards model univariate and multivariate analyses of individual parameters for correlations with overall survival (OS).
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | CI (95%) | P value∗ | HR | CI (95%) | P value∗ | |
| Age | ||||||
| <65 years | 1 | — | ||||
| ≥65 years | 0.611 | 0.374–0.998 | 0.051 | |||
| Gender | ||||||
| Male | 1 | — | ||||
| Female | 1.070 | 0.667–1.714 | 0.780 | |||
| AJCC stage | ||||||
| I and II | 1 | — | 1 | — | ||
| III and IV | 0.364 | 0.225–0.590 | <0.001∗ | 0.458 | 0.277–0.756 | 0.002∗ |
| T stage | NR | |||||
| T1 and T2 | 1 | — | ||||
| T3 and T4 | 0.342 | 0.138–0.851 | 0.021∗ | |||
| Lymph node metastasis | NR | |||||
| Negative | 1 | — | ||||
| Positive | 0.418 | 0.260–0.672 | <0.001∗ | |||
| Distant metastasis | NR | |||||
| M0 | 1 | — | ||||
| M1 | 0.144 | 0.075–0.276 | <0.001∗ | |||
| Differentiation | ||||||
| Well and moderate | 1 | — | 1 | — | ||
| Poor | 0.451 | 0.279–0.728 | 0.001∗ | 0.539 | 0.329–0.883 | 0.014∗ |
| GRK3 expression | ||||||
| Negative | 1 | — | 1 | — | ||
| Weak and strong | 0.375 | 0.201–0.698 | 0.002∗ | 0.424 | 0.226–0.797 | 0.008∗ |
HR: hazard radio; CI: confidence interval; NR: variable was not included in the resultant model. ∗Significance indicated that the 95% CI of HR was not including 1.