Table 1.
Baseline Demographic Data
| Renal Classification According to CrCla | |||||
|---|---|---|---|---|---|
| Normal (n = 6) | Mild (n = 6) | Moderate (n = 6) | Severe (n = 6) | ESRD (n = 6) | |
| Age, mean (SD), years | 64.2 (5.2) | 61.7 (6.5) | 62.3 (14.9) | 70.5 (8.5) | 65.5 (8.7) |
| Sex, M:F | 2:4 | 2:4 | 4:2 | 4:2 | 4:2 |
| Weight, mean (SD), kg | 65.4 (10.7) | 62.5 (8.4) | 69.3 (14.7) | 59.5 (11.7) | 60.6 (9.1) |
| BMI, median (range), kg/m2 | 25.9 (22.4–27.7) | 24.6 (20.7–26.8) | 25.1 (19.4–28.8) | 24.1 (19.9–28.7) | 24.4 (20.4–26.5) |
| Estimated CrCl, mean (SD), mL/min/1.73 m2 | 100.3 (11.4) | 69.8 (8.0) | 40.9 (6.2) | 23.4 (5.8) | 9.7 (3.2) |
BMI, body mass index; CrCl, creatinine clearance;12 ESRD, end‐stage renal disease; F, female; M, male; SD, standard deviation.
a
Renal function groups, based on the Cockcroft‐Gault formula,12 were normal (estimated CrCl > 80 mL/min/1.73 m2), mild impairment (50 mL/min/1.73 m2 ≤ CrCl ≤ 80 mL/min/1.73 m2), moderate impairment (30 mL/min/1.73 m2 ≤ CrCl < 50 mL/min/1.73 m2), severe impairment (CrCl < 30 mL/min/1.73 m2), and ESRD (patients undergoing hemodialysis, regardless of CrCl).