Table 6.

Adverse events by severity

Adverse Events	Grade 1	Grade 2	Grade 3	Grade 4
Leukopenia	7 (15.2)	0 (0)	0 (0)	0 (0)
Thrombocytopenia	2 (4.3)	2 (4.3)	1 (2.2)	1 (2.2)
Agranulocytosis	0 (0)	0 (0)	3 (6.5)	2 (4.3)
Agranulocytotic fever	0 (0)	0 (0)	1 (2.2)	1 (2.2)
Hyperbilirubinemia	1 (2.2)	0 (0)	0 (0)	0 (0)
Hypofibrinogenemia	2 (4.3)	0 (0)	0 (0)	0 (0)
Liver dysfunction	11 (23.9)	5 (10.9)	1 (2.2)	0 (0)
Renal dysfunction	1 (2.2)	0 (0)	0 (0)	0 (0)
Nausea	11 (23.9)	0 (0)	0 (0)	0 (0)
Vomiting	10 (21.7)	0 (0)	0 (0)	0 (0)