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. 2017 Dec 21;11(Suppl 7):129. doi: 10.1186/s12918-017-0513-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Parameters in the WB-PBPK model for irinotecan and the metabolites. Parameters are shown in the WB-PBPK model for irinotecan and the metabolites. a The kinds of parameters other than the metabolites in liver are same among irinotecan and the metabolites. Indicated are the blood flow (Q), the volume (V), the tissue-plasma partition coefficient (Kp), renal clearance (CL_r), biliary clearance to transit compartment (CL_bile), absorption rate constant (k_a), kinetic constant for the transit in bile compartments to small intestine (k_bile), kinetic constants for the transit from small intestine to large intestine (k_L.I.), kinetic constant for the transit from large intestine to feces (k_feces), hepatic artery (H.A.) and hepatic vein (H.V.). The metabolic pathway of irinotecan and the metabolites in liver are represented b. Indicated are metabolic clearance of CPT-11 by CES2 to form SN-38 (CL_CES,1), metabolic clearance of NPC by CES2 to form SN-38 (CL_CES,2), metabolic clearance of CPT-11 by CYP3A4 to form APC (CL_3A4,1), metabolic clearance of CPT-11 by CYP3A4 to form NPC (CL_3A4,2) and metabolic clearance of SN-38 by UGT to form SN-38G (CL_UGT)