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Distributions of parameters with strong convergences after second CNM with the fixed values of Kp. The distributions of the optimized values of the parameters with strong convergence are described after the parameter estimations by the CNM with the fixed values of Kp. The distributions of parameter #71 (renal clearance of CPT-11), #76 (liver clearance to bile of CPT-11), and #83 (liver metabolism from CPT-11 to APC) are shown in (a), (b) and (c), respectively
