Table 1.

Patient characteristics, dose of irinotecan and physiological parameters

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Patient 7
Sex	Men	Men	Men	Men	Female	Female	Female
Age (years)	73	67	51	70	74	52	71
Height (cm)	171.6	169.4	182.3	182.5	170.6	169.4	188.6
Weight (kg)	109.1	89.1	78.6	98.2	88.0	52.7	83.2
BMI (kg/m2)a	37.1	31.0	23.7	29.5	30.2	18.4	23.4
Dose (μg/kg)	1000	1500	1700	1100	1400	2200	1400
Duration of infusion (min)	90	90	90	90	90	90	90
Volume (ml/kg)b
Venous blood	12.8	15.6	18.7	14.9	12.3	20.4	14.0
Artery blood	8.1	9.8	11.7	9.4	7.7	12.8	8.8
Lung	11.6	14.1	16.9	13.5	11.9	19.7	13.5
Heart	3.8	4.5	5.4	4.4	3.9	6.4	4.4
Brain	13.8	16.9	19.2	15.4	15.4	25.7	16.3
Muscle	290.8	352.7	422.4	338.4	238.4	396.0	271.9
Adipose	469.0	360.6	240.0	391.2	516.4	210.8	452.6
Skin	41.7	46.0	50.3	40.3	38.1	49.1	40.7
Bone	106.3	128.9	154.4	123.7	107.3	178.2	122.3
Kidney	3.9	4.8	5.7	4.6	4.7	7.9	5.4
Spleen	2.2	2.7	3.2	2.5	2.6	4.3	2.9
Pancreas	1.7	2.1	2.5	2.0	2.0	3.3	2.3
Stomach	1.5	1.8	2.2	1.8	1.9	3.2	2.2
Small Intestine	6.5	7.9	9.5	7.6	8.2	13.6	9.3
Large Intestine	3.7	4.5	5.4	4.3	4.9	8.1	5.6
Liver	21.2	25.7	30.8	24.7	22.4	37.2	25.5
Blood flow Rate (ml/min/kg)b
Lung	54.9	66.6	79.8	63.9	64.7	107.5	73.8
Heart	2.3	2.8	3.4	2.7	3.5	5.8	4.0
Brain	7.0	8.5	10.2	8.2	8.3	13.8	9.5
Muscle	9.9	12.1	14.4	11.6	7.8	13.0	8.9
Adipose	2.9	3.5	4.2	3.4	5.9	9.8	6.7
Skin	2.9	3.5	4.2	3.4	3.5	5.8	4.0
Bone	2.9	3.5	4.2	3.4	3.5	5.8	4.0
Kidney	11.9	14.5	17.3	13.9	13.2	21.9	15.0
Spleen	1.8	2.1	2.5	2.0	2.1	3.5	2.4
Pancreas	0.6	0.7	0.8	0.7	0.7	1.2	0.8
Stomach	0.6	0.7	0.8	0.7	0.7	1.2	0.8
Small Intestine	5.8	7.1	8.5	6.8	7.6	12.7	8.7
Large Intestine	2.3	2.8	3.4	2.7	3.5	5.8	4.0
Liver (Total)	14.9	18.1	21.7	17.3	18.7	31.1	21.4
Liver (Artery)	3.8	4.6	5.5	4.4	4.5	7.5	5.1

BMI, body-mass index

^aBMI is calculated as weight(kg)÷height(m)2

^bVolume and blood flow rate for each vessel and organ are calculated by using the work of Willmann et al. [15]