Table 2.
Objective values for each patient
| ID | Parameters | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 |
|---|---|---|---|---|---|---|---|---|
| Urinary elimination ratio (%) | ||||||||
| 1 | CPT-11 | 23.2 | 25.5 | 35.5 | 26.3 | 17.8 | 28.1 | 30.0 |
| 2 | SN-38 | 0.4 | 0.5 | 0.7 | 0.5 | 0.3 | 0.5 | 0.6 |
| 3 | SN-38G | 3.1 | 3.4 | 4.8 | 3.6 | 2.4 | 3.8 | 4.0 |
| 4 | NPC | 0.1 | 0.2 | 0.2 | 0.2 | 0.1 | 0.2 | 0.2 |
| 5 | APC | 2.3 | 2.5 | 3.5 | 2.6 | 1.8 | 2.8 | 3.0 |
| Fecal elimination ratio (%) | ||||||||
| 6 | CPT-11 | 45.3 | 43.5 | 35.4 | 42.7 | 49.6 | 41.4 | 39.9 |
| 7 | SN-38 + SN-38G | 11.9 | 11.4 | 9.3 | 11.2 | 13.1 | 10.9 | 10.5 |
| 8 | NPC | 1.9 | 1.8 | 1.5 | 1.8 | 2.1 | 1.7 | 1.7 |
| 9 | APC | 11.6 | 11.2 | 9.1 | 11.0 | 12.7 | 10.6 | 10.2 |
| Cmax (μg/ml) | ||||||||
| 10 | CPT-11 | 1.53 | 1.53 | 1.53 | 1.53 | 1.53 | 1.53 | 1.53 |
| 11 | SN-38 | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 | 0.04 |
| 12 | SN-38G | 0.09 | 0.09 | 0.09 | 0.09 | 0.09 | 0.09 | 0.09 |
| 13 | APC | 0.19 | 0.19 | 0.19 | 0.19 | 0.19 | 0.19 | 0.19 |
Cmax, maximum serum concentrations
The total elimination ratio of urine and feces is normalized to the ratio of reported individual information. Ratios of metabolism from CPT-11 to its metabolites and Cmax of all compounds use average values in the report. Cmax of the metabolites are normalized to the amount of CPT-11