Fig. 2.

A toy example of illustrating three kinds of LDAs involving 3 lncRNAs and 4 diseases. The first row shows a 3×5 binary lncRNA-protein interaction matrix, a 5×5 protein similarity matrix and a 5×4 binary gene-disease association matrix from left to right. The second row lists three kinds of 3×4 LDA matrices, including a binary matrix, a discrete matrix, and a continued matrix. The entries highlighted by different colors in discrete and continued matrices have different values. Binary LDA provides a coarse information about how a lncRNA is associated with a disease, while discrete LDA and continue LDA provide the number of proteins involved in LDA and the intensity of LDA for that question respectively