Table 3.
Example of gene pairs which are molecularly non-interacting but dynamically influential (MNDI)
Network | Gene pairs | Sub-graph | μ(v i, v j) | l(v i, v j) |
---|---|---|---|---|
AMRN | EMF1, AG | EMF1→ TFL1⊣ AG | 0.146 | 2 |
TFL1, AP1 | TFL1⊣ LFY→ AP1 | 0.0125 | 2 | |
ABAN | ABA, S1P | ABA→ SphK→ S1P | 0.498 | 2 |
ABA, NIA12 | ABA→ RCN1→ NIA12 | 0.498 | 2 | |
HSN | CSK, BCR | CSK⊣ LYN→ BCR | 0.503 | 2 |
GHR, IGF1R | GHR→ IGF1→ IGF1R | 0.382 | 2 |
Source and target genes are represented by orange- and green-colored nodes, respectively. Sub-graph field means the shortest path with respect to the gene pair in the GMI network. Arrow-headed (→) and bar-headed (⊣) lines indicate activating (positive) and inhibitory (negative) interactions, respectively