Fig. 4.

CLO design pattern model for using the new shortcut relation ‘derives originally from patient having disease’. a General design pattern; b an example to illustrate the design pattern. The shortcut relation makes it more efficient to represent the relation between a cell line cell and a disease when the parent term of the cell line cell includes sufficient information about the cell type and tissue/organ. In this illustration, the classes as shown in the dotted boxes are redundant and are not needed