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. 2016 Aug 30;38(1):87–92. doi: 10.1111/cpf.12387

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© 2016 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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CVR and task‐related activation maps overlaid on the individuals' T1‐weighted images in standard space for sensorimotor regions. R=right, L=left, coordinates refer to MNI space. Motor cortex CVR (top row) and task‐related activation during the separate motor task (middle row) and combined visual–motor task (bottom row) for an illustrative control (a), patient 1 preoperatively (b), and patient 2 preoperatively (c). Robust positive CVR was observed in the control, whereas the patients had large areas of negative or absent CVR, particularly over the affected (right) hemispheres. As expected, task activation was bilateral in the control participant (a). In the patients (b and c), activation was more lateralized during the combined task than the separate task, with reduced or absent activation over the affected hemisphere during the combined task (pink circles).