Table 2.
Univariate logistic regression analysis showing the clinical features that differed across the clusters derived by HC using the four informative features/domains (dichotomous definition of allergic sensitization)
| Feature/domain | Cluster 1 (n = 132) “Difficult asthma” | Cluster 2 (n = 210) “Early‐onset mild atopic asthma” | Cluster 3 (n = 153) “Early‐onset mild non‐atopic asthma” | Cluster 4 (n = 105) “Late‐onset asthma” | Cluster 5 (n = 13) “Exacerbation‐prone asthma” | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Coeffa Mean (95%CI) or frequency (%) | P‐value | Coeff Mean (95%CI) or frequency (%) | P‐value | Coeff Mean (95%CI) or frequency (%) | P‐value | Coeff Mean (95%CI) or frequency (%) | P‐value | Coeff Mean (95%CI) or frequency (%) | P‐value | |
| Age of Onset | −0.03 | .04 | −0.10 | <.001 | −0.12 | <.001 | 0.26 | <.001 | −0.008 | .14 |
| Years | 4.9 (2.3‐7) | 4.4 (3‐6) | 3.8 (2‐6) | 10.7 (9‐12) | 4.1 (2‐5) | |||||
| Asthma attacks | 0.008 | .96 | −0.04 | .04 | −0.04 | .02 | −0.04 | .007 | 0.12 | <.001 |
| Number, previous year | 1.0 (0‐1) | 0.8 (0‐1) | 0.9 (0‐1) | 0.4 (0‐1) | 3.5 (0‐7) | |||||
| Allergic sensitization | −0.002 | .88 | 0.29 | <.001 | −0.29 | <.001 | 0.01 | .26 | −0.002 | .71 |
| Sensitized | 77/132 (58%) | 183/210 (87%) | 27/153 (18%) | 67/105 (64%) | 7/13 (54%) | |||||
| Asthma severity | 0.38 | <.001 | −0.17 | <.001 | −0.13 | <.001 | −0.08 | <.001 | 0.006 | .27 |
| Mild | 46/132 (35%) | 190/210 (90%) | 141/153 (92%) | 91/105 (87%) | 8/13 (62%) | |||||
| Moderate/severe | 86/132(65%) | 20/210 (10%) | 12/153 (8%) | 14/105 (13%) | 5/13 (38%) | |||||
| Cluster stability | 1.00 | 0.99 | 0.99 | 1.00 | 1.00 | |||||
Quantitative variables are represented as mean (95% CI). Ordinal variables are represented as frequencies (%).
a
Coeff: The coefficient translates into a value of how likely a child is assigned to that cluster based on the variable response. Bolded values represent significant p‐values.